Do cold sores have any long-term health risks?

cold sores 2

The herpes simplex virus (HSV) is a common sexually transmitted virus. The name comes from the ancient Greek word ‘herpein’, meaning ‘to creep or crawl’, which suggests both the pattern of blister development as well as how successfully the virus has survived over time.

Two subtypes exist; HSV 1 and HSV 2, both of which are spread through close personal contact via mucous membranes — a less than pleasant term for the epithelial cells found covering the cheeks, tongue, and the glans (head) of the penis, as well as the vagina and rectum. HSV 1 and HSV 2 can both affect either the mouth or genitals, but HSV 1 is oral in 95% of cases and HSV 2 preponderantly affects the genital area, though numbers are hard to pin down. HSV 1 and 2 are spread principally through exchange of saliva or through oral sex.

The classical course of an HSV flare is a mild flu-like illness, followed by tingling, itching or burning sensations where herpetic blisters are soon to form. Eruption of fluid filled blisters occurs over affected areas, which pop and scab over before healing over two to four weeks, followed by a symptom free period.

HSV 1 is very prevalent; close to four billion people carry the virus, many unknowingly due to infrequent or trivial symptoms. HSV oral blisters are commonly known as “cold sores”, which can be spread through oral sex to the genitals of the unaffected partner, causing HSV 1 genital herpes, a less severe variant of the illness. Transmission is more likely when cold sores are present, but the skin still sheds infectious viral particles even when lesions are absent. Interestingly HSV 1 is partially protective against HSV 2; the antibodies we develop provide cross-protection against both viral subtypes.1

Four in five cases of genital herpes are caused by HSV 2, and despite being less common – around one in six people in the developed world have genital herpes – genital herpes is what most people commonly understand by the term ‘herpes’. Once infected with a herpes virus the infection is lifelong; during quiescent phases HSV 1 typically resides in the trigeminal nerve, which supplies the face. Between outbreaks HSV 2 tends to reside in the sacral ganglia, a cluster of nervous tissue around the tailbone.

As many as eight in ten people with genital herpes do not realise they are infected as they experience few or no symptoms. As with other sexually transmitted viruses (HPV, genital warts, hepatitis B) it’s a genetic lottery whose immune system can fight off the virus well enough to prevent symptoms.

Long term effects and treatment

As with many viruses, the body’s immune system is the best defence we have. No vaccine yet exists for HSV, and anti-viral medications are of limited benefit and not recommended for routine use. HSV flares are self-limiting and only rarely scar, so the best advice is to make use of the simple painkillers paracetamol and ibuprofen during flares, and apply topical (liquid or cream) lidocaine-based solutions to relieve pain. When persistent, severe or prolonged flares occur, a doctor may consider prescribing an oral antiviral such as valacyclovir, which have evidence for reducing the length of outbreaks.2

Those with genetic immune problems, or immunocompromising illnesses like HIV, are at an increased risk of complications of HSV. If HSV moves from the peripheral nerves up to the “central” nervous system (the brain), progressive confusion and loss of consciousness occurs. In these cases prompt treatment with intravenous acyclovir in hospital minimises risk to life, unfortunately the general population also suffers from central HSV infection, though rarely (two per million people per year).3

The Roman emperor Tiberius outlawed kissing in public in an effort to halt an outbreak of herpes; not a bad guess considering the germ theory of disease was still a couple of thousand years away. To minimise your chances of contracting oral HSV, avoid kissing partners during a flare (when cold sores are visible), and limiting the sharing of mugs, lip balm or water bottles with friends is a reasonable precaution.

Barrier protection methods (like condom use) during sex make a significant dent in transmission rates — around 40% less risk — but provide imperfect protection as other skin to skin contact in the genital area, especially with friction, may transmit viral particles. The other best advice would be to avoid sexual contact before, during or immediately after your partner has active blistering lesions. This is possible if the partner in question experiences prodromal symptoms such as itching or burning that they can recognise as an imminent outbreak.

Pregnancy

In pregnancy if you notice any symptoms that suggest of genital herpes it is important to highlight this to the team monitoring your pregnancy; caesarean section is the safest way to deliver these babies, especially when the diagnosis is in the final trimester.

The biggest risk factors for transmitting HSV from mum to baby include mum being HIV positive, which interferes with her immune response, and mum contracting HSV during pregnancy, especially the last trimester. In the majority of cases the baby contracts HSV during passage through the birth canal, though transmission in utero can also occur.

Unfortunately, infants are a group vulnerable to HSV infection due to their immature immune systems. Infant herpes can be limited to the skin, eyes and mouth, or may involve internal organs, especially the liver and brain. This can be fatal for babies, or cause long term damage to organs involved. Risk factors for neonatal HSV, that is primary herpes infection during pregnancy, include young maternal age, first pregnancy and receptive oral sex in the third trimester.

If a woman acquires HSV in the third trimester there is no time for her immune system to form the antibodies which normally circulate through the maternal bloodstream, placenta and into the baby to provide a protective effect at birth. All this in mind, it’s important to remember that unless you have HSV blisters on your breasts or nipples (which is rare) breastfeeding your baby is still perfectly safe if you have HSV.

For women with recurrent genital herpes, the risk of HSV infection to their newborn is low, even if blisters are present at birth (1-3% for vaginal delivery).4 Taking a drug called acyclovir from thirty-six weeks of pregnancy lowers the risk of outbreaks before delivery and hence the need for caesarean section.

In summary, HSV is an extremely common virus with an undue social stigma. There are no failsafe ways to avoid the virus other than omitting all human contact. Either strain can be managed and outbreaks tend to become less frequent over time, so don’t despair if you have HSV — you are by no means alone.

References

  1. G. M. Andria et al., ‘A Prospective Study of New Infections with Herpes Simplex Virus Type 1 and Type 2’, N Engl J Med, Vol. 341, 1999, pp. 1432-1438.
  2. W. Opstelten et al., ‘Treatment and prevention of herpes labialis’, Can Fam Physician, vol. 54, no. 12, 2008, pp. 1683-1687.
  3. R. J. Whitley, ‘Herpes simplex encephalitis: adolescents and adults’, Antiviral Res., Vol. 71, No. 2-3, 2006, pp. 141-8.
  4. S. H. James et al., ‘Mother-to-Child Transmission of Herpes Simplex Virus’, J Pediatric Infect Dis Soc., Vol. 3, Suppl. 1, 2014, pp. S19-S23.

Dr. Charles Mercer MBBS, MClinEd

Charles studied medicine at Durham and Newcastle, where he was awarded a scholarship to stay for a master’s degree in medical education. He is interested in child and maternal health, as well as medical education. He is currently working towards his membership exams for the Royal College of Paediatrics and Child Health, while working as a paediatrician.

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